作者
Krekwit Shinlapawittayatorn, Kroekkiat Chinda, Siripong Palee, Sirirat Surinkaew, Kittiya Thunsiri, Punate Weerateerangkul, Siriporn Chattipakorn, Bruce H KenKnight, Nipon Chattipakorn
发表日期
2013/11/1
期刊
Heart rhythm
卷号
10
期号
11
页码范围
1700-1707
出版商
Elsevier
简介
Background
Right cervical vagus nerve stimulation (VNS) provides cardioprotective effects against acute ischemia-reperfusion injury in small animals. However, inconsistent findings have been reported.
Objective
To determine whether low-amplitude, left cervical VNS applied either intermittently or continuously imparts cardioprotection against acute ischemia-reperfusion injury.
Methods
Thirty-two isoflurane-anesthetized swine (25–30 kg) were randomized into 4 groups: control (sham operated, no VNS), continuous-VNS (C-VNS; 3.5 mA, 20 Hz), intermittent-VNS (I-VNS; continuously recurring cycles of 21-second ON, 30-second OFF), and I-VNS + atropine (1 mg/kg). Left cervical VNS was applied immediately after left anterior descending artery occlusion (60 minutes) and continued until the end of reperfusion (120 minutes). The ischemic and nonischemic myocardium was harvested for cardiac mitochondrial function …
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