作者
Chayodom Maneechote, Siripong Palee, Siriporn C Chattipakorn, Nipon Chattipakorn
发表日期
2017/11
来源
Journal of Cellular and Molecular Medicine
卷号
21
期号
11
页码范围
2643-2653
简介
The current therapeutic strategy for the management of acute myocardial infarction (AMI) is to return blood flow into the occluded coronary artery of the heart, a process defined as reperfusion. However, reperfusion itself can increase mortality rates in AMI patients because of cardiac tissue damage and dysfunction, which is termed ‘ischaemia/reperfusion (I/R) injury’. Mitochondria play an important role in myocardial I/R injury as disturbance of mitochondrial dynamics, especially excessive mitochondrial fission, is a predominant cause of cardiac dysfunction. Therefore, pharmacological intervention and therapeutic strategies which modulate the mitochondrial dynamics balance during I/R injury could exert great beneficial effects to the I/R heart. This review comprehensively summarizes and discusses the effects of mitochondrial fission inhibitors as well as mitochondrial fusion promoters on cardiac and mitochondrial …
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C Maneechote, S Palee, SC Chattipakorn… - Journal of Cellular and Molecular Medicine, 2017