作者
Noppamas Pipatpiboon, Hiranya Pintana, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakorn
发表日期
2013/3
期刊
European Journal of Neuroscience
卷号
37
期号
5
页码范围
839-849
简介
High‐fat diet (HFD) consumption has been demonstrated to cause peripheral and neuronal insulin resistance, and brain mitochondrial dysfunction in rats. Although the dipeptidyl peptidase‐4 inhibitor, vildagliptin, is known to improve peripheral insulin sensitivity, its effects on neuronal insulin resistance and brain mitochondrial dysfunction caused by a HFD are unknown. We tested the hypothesis that vildagliptin prevents neuronal insulin resistance, brain mitochondrial dysfunction, learning and memory deficit caused by HFD. Male rats were divided into two groups to receive either a HFD or normal diet (ND) for 12 weeks, after which rats in each group were fed with either vildagliptin (3 mg/kg/day) or vehicle for 21 days. The cognitive function was tested by the Morris Water Maze prior to brain removal for studying neuronal insulin receptor (IR) and brain mitochondrial function. In HFD rats, neuronal insulin resistance …
学术搜索中的文章
N Pipatpiboon, H Pintana, W Pratchayasakul… - European Journal of Neuroscience, 2013