作者
Christopher W White, Devin Hasanally, Paul Mundt, Yun Li, Bo Xiang, Julianne Klein, Alison Müller, Emma Avery, Amir Ravandi, Rakesh C Arora, Trevor W Lee, Larry V Hryshko, Stephen Large, Ganghong Tian, Darren H Freed
发表日期
2015/1/1
期刊
The Journal of Heart and Lung Transplantation
卷号
34
期号
1
页码范围
113-121
出版商
Elsevier
简介
Background
Ex vivo heart perfusion (EVHP) provides the opportunity to resuscitate unused donor organs and facilitates assessments of myocardial function that are required to demonstrate organ viability before transplantation. We sought to evaluate the effect of different oxygen carriers on the preservation of myocardial function during EVHP.
Methods
Twenty-seven pig hearts were perfused ex vivo in a normothermic beating state for 6 hours and transitioned into working mode for assessments after 1 (T1), 3 (T3), and 5 (T5) hours. Hearts were allocated to 4 groups according to the perfusate composition. Red blood cell concentrate (RBC, n = 6), whole blood (RBC+Plasma, n = 6), an acellular hemoglobin-based oxygen carrier (HBOC, n = 8), or HBOC plus plasma (HBOC+Plasma, n = 7) were added to STEEN Solution (XVIVO Perfusion, Goteborg, Sweden) to achieve a perfusate hemoglobin concentration of 40 g/liter …
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CW White, D Hasanally, P Mundt, Y Li, B Xiang, J Klein… - The Journal of Heart and Lung Transplantation, 2015