作者
Jaime Kulisevsky, Carmen García‐Sánchez, Marcelo L Berthier, Manel Barbanoj, Berta Pascual‐Sedano, Alexandre Gironell, Armando Estévez‐González
发表日期
2000/7
期刊
Movement disorders: official journal of the Movement Disorder Society
卷号
15
期号
4
页码范围
613-626
出版商
John Wiley & Sons, Inc.
简介
BACKGROUND
The cognitive effects of dopaminergic treatment in Parkinson's disease (PD) are still controversial.
OBJECTIVE
To evaluate, in previously untreated patients with PD, whether chronic dopaminergic stimulation produces significant cognitive changes; whether they are sustained beyond the period of a few months; and whether the cognitive status of two motor‐comparable groups is differently affected by levodopa and pergolide.
DESIGN AND SUBJECTS
Parallel, randomized open study with blind neuropsychologic evaluation of 20 consecutive de novo patients with PD before and 3, 6, 12, 18, and 24 months after monotherapy with levodopa (n = 10) or pergolide (n = 10; 6‐month monotherapy; pergolide + levodopa thereafter).
RESULTS
Both treatments were associated with a significant improvement in motor scores and in tests assessing learning and long‐term verbal and visual memory …
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J Kulisevsky, C García‐Sánchez, ML Berthier… - Movement disorders: official journal of the Movement …, 2000