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Abstract Curdlan (CN)-doped montmorillonite/poly (N-isopropylacrylamide-co-N, N′-methylene-bis-acrylamide)[CN/MT/P (NIPA-co-MBA)] smart nanocomposites (NCs) were developed for efficient erlotinib HCl (ERL) delivery to lung cancer cells. The placebo NCs demonstrated excellent biodegradability, pH/thermo-responsive swelling profiles and declined molar mass (M¯ c) between the crosslinks with increasing temperature. The XRD, FTIR, DSC, TGA, and SEM analyses revealed the architectural chemistry of these NC scaffolds. The NCs loaded with ERL (F-1-F-3) displayed acceptable diameter (734–1120 nm) and zeta potential (+ 1.16 to− 11.17 mV), outstanding drug entrapping capability (DEE, 78–99%) and sustained biphasic ERL elution patterns (Q 8h, 53–91%). The ERL release kinetics of the optimal matrices (F-3) obeyed Higuchi model and their transport occurred through anomalous diffusion. The …