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Oxaliplatin (OHP) resistance is a major hurdle in the chemotherapeutic treatment of colorectal cancer (CRC). The present study aimed to formulate Eudragit S-100 (ES-100) coated alginate beads bearing drugs loaded targeted liposomes for simultaneous delivery of OHP and curcumin (CUR) to exert a synergistic therapeutic effect on OHP- resistant HT-29 cell line.

The liposomes were prepared by the thin-film hydration method and optimized for various formulation parameters using a Box-Behnken design (BBD) with the aid of Design-Expert® software. Hyaluronic acid (HA) was conjugated on the liposomal surface using carbodiimide chemistry to target CD44 receptors, which are overexpressed on the CRC cells. HA coupled drugs bearing liposomes (OC-L-HA) were then characterized for various attributes, viz. shape, surface-morphology, size, zeta potential, PDI, entrapment efficiency …