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The sandal tree, also known as Chandana in India, is botanically Santalum album L belonging to family Santalaceae. The average yield of oil ranges from 4.5-2.5%. The sweet powerful and lasting odor makes Sandalwood oil useful in perfume industry. The fragrant parts of sandalwood oil constitutes of α-and β santalols. Sandalwood oil, the essential oil of santalum album L has been tested for invitro antiviral activity against Herpes simplex viruses-1 & 2. The sedative effect of sandalwood oil as well as HESP oil on albino mice of either sex in dose of 500/600 mg/kg. Skin cancerand chemo preventive efficacy of α-Santalol. KH Shankarnarayana et al investigated the anti-inflammatory effect of sandalwood oil as well as HESP oil against yeast induced pyrexia in albino rats. A significantly high antipyretic effect observed in case of sandalwood oil and HESP and astringent activity, making it useful as disinfectant in genitourinary and bronchial tracts, diuretic, expectorant and stimulant.