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In order to achieve high bioactivity, low systemic side effects and prevention of high critical hypoglycaemic conditions of antidiabetic drugs in the treatment of diabetes mellitus, sustained and controlled delivery system is crucial. In this study, a three-dimensional (3-D) porous scaffold formulation was developed with the ability to release antidiabetic drugs in a controlled fashion. The gliclazide (GLZ), was successfully incorporated into prefabricated 3-D porous matrix chitosan scaffolds using a freeze-drying method. Porosity, swelling, water absorption and drug entrapment efficiency was increased after the addition of PEG 4000. The release kinetics of GLZ from two different (2% and 3%) chitosan scaffold formulations investigated showed sustained and controlled delivery of GLZ. The GLZ release is strongly dependent upon the physical and chemical properties of the chitosan and PEG 4000. Scaffold with 3% chitosan …