作者
Ivan FN Hung, Kelvin KW To, Cheuk-Kwong Lee, Kar-Lung Lee, Kenny Chan, Wing-Wah Yan, Raymond Liu, Chi-Leung Watt, Wai-Ming Chan, Kang-Yiu Lai, Chi-Kwan Koo, Tom Buckley, Fu-Loi Chow, Kwan-Keung Wong, Hok-Sum Chan, Chi-Keung Ching, Bone SF Tang, Candy CY Lau, Iris WS Li, Shao-Haei Liu, Kwok-Hung Chan, Che-Kit Lin, Kwok-Yung Yuen
发表日期
2011/2/15
期刊
Clinical Infectious Diseases
卷号
52
期号
4
页码范围
447-456
出版商
Oxford University Press
简介
Background. Experience from treating patients with Spanish influenza and influenza A(H5N1) suggested that convalescent plasma therapy might be beneficial. However, its efficacy in patients with severe pandemic influenza A(H1N1) 2009 virus (H1N1 2009) infection remained unknown.
Methods. During the period from 1 September 2009 through 30 June 2010, we conducted a prospective cohort study by recruiting patients aged ≥18 years with severe H1N1 2009 infection requiring intensive care. Patients were offered treatment with convalescent plasma with a neutralizing antibody titer of ≥1:160, harvested by apheresis from patients recovering from H1N1 2009 infection. Clinical outcome was compared with that of patients who declined plasma treatment as the untreated controls.
Results. Ninety-three patients with severe H1N1 2009 infection …
学术搜索中的文章
IFN Hung, KKW To, CK Lee, KL Lee, K Chan, WW Yan… - Clinical Infectious Diseases, 2011