作者
Sulafa Abdulla Alsahlawi and Hany Aly Hassan Mohammad 1Promise Madu Emeka, Haya Mohammed Almofarfesh
发表日期
2021/2/8
期刊
Asian Journal of Plant Sciences
卷号
20
页码范围
355-362
出版商
Science Alert
简介
Background and Objective
Paclitaxel (PTX) is an effective anticancer agent but in the same fashion, has a major dose-limiting haematological toxicity. Taraxacum officinale (TXO) crude extract has been used in the treatment of anaemia in herbal remedies. Here, this study evaluated the possible attenuation of PTX-induced haematological adverse effects and lipid peroxidation with coadministration of TXO crude extract.
Materials and Methods
The whole plant of TXO was soaked in water for 24 hrs, filtered, and evaporated to dryness with rotary evaporator. Five groups of 6 adult rats weighing between 150-160 g were used. Normal saline was administered to control group 1, group 2 was given 30 mg kgG 1 of PTX alone intraperitoneally. Group 3 and 4 were given PTX 30 mg kgG 1 followed by 200 and 400 mg kgG 1 TXO respectively. The fifth group received 200 mg kgG 1 TXO alone. Drug administration lasted for 10 …
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