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Around mid‐life, ovarian production of estrogen stops in a sex‐specific endocrine transition called menopause. While most women who have dementia are post‐menopausal, menopause is seldom included in rodent models of dementia despite its significance in dementia risk factors in women. Before, but not after menopause, women are less likely than men to suffer from stroke, obesity, and diabetes: known risk factors for vascular contributions to cognitive impairment and dementia (VCID). Here, we aim to determine if and how menopause worsens VCID. We hypothesize that menopause will increase metabolic dysfunction, cognitive impairment, and brain pathology in a mouse model of VCID. To model menopause, we utilized 4‐vinylcyclohexene diepoxide to induce accelerated ovarian failure. To model VCID, we performed a unilateral common carotid artery occlusion surgery. We assessed cognitive deficits …