作者
Renato D Lopes, Roberto Rordorf, Gaetano M De Ferrari, Sergio Leonardi, Laine Thomas, Daniel M Wojdyla, Peter Ridefelt, John H Lawrence, Raffaele De Caterina, Dragos Vinereanu, Michael Hanna, Greg Flaker, Sana M Al-Khatib, Stefan H Hohnloser, John H Alexander, Christopher B Granger, Lars Wallentin, ARISTOTLE Committees and Investigators
发表日期
2018/3/13
期刊
Journal of the American College of Cardiology
卷号
71
期号
10
页码范围
1063-1074
出版商
American College of Cardiology Foundation
简介
Background
Digoxin is widely used in patients with atrial fibrillation (AF).
Objectives
The goal of this paper was to explore whether digoxin use was independently associated with increased mortality in patients with AF and if the association was modified by heart failure and/or serum digoxin concentration.
Methods
The association between digoxin use and mortality was assessed in 17,897 patients by using a propensity score–adjusted analysis and in new digoxin users during the trial versus propensity score–matched control participants. The authors investigated the independent association between serum digoxin concentration and mortality after multivariable adjustment.
Results
At baseline, 5,824 (32.5%) patients were receiving digoxin. Baseline digoxin use was not associated with an increased risk of death (adjusted hazard ratio [HR]: 1.09; 95% confidence interval [CI]: 0.96 to 1.23; p = 0.19). However, patients …
学术搜索中的文章
RD Lopes, R Rordorf, GM De Ferrari, S Leonardi… - Journal of the American College of Cardiology, 2018