作者
Barbara Yang, Hazel Wilkie, Mrinmoy Das, Maheshwor Timilshina, Wayne Bainter, Brian Woods, Michelle Daya, Meher P Boorgula, Rasika A Mathias, Peggy Lai, Carter R Petty, Edie Weller, Hani Harb, Talal A Chatila, Donald YM Leung, Lisa A Beck, Eric L Simpson, Tissa R Hata, Kathleen C Barnes, Wanda Phipatanakul, Juan-Manuel Leyva-Castillo, Raif S Geha
发表日期
2023/5/1
期刊
Journal of Allergy and Clinical Immunology
卷号
151
期号
5
页码范围
1296-1306. e7
出版商
Mosby
简介
Background
Atopic dermatitis (AD) is characterized by TH2-dominated skin inflammation and systemic response to cutaneously encountered antigens. The TH2 cytokines IL-4 and IL-13 play a critical role in the pathogenesis of AD. The Q576->R576 polymorphism in the IL-4 receptor alpha (IL-4Rα) chain common to IL-4 and IL-13 receptors alters IL-4 signaling and is associated with asthma severity.
Objective
We sought to investigate whether the IL-4Rα R576 polymorphism is associated with AD severity and exaggerates allergic skin inflammation in mice.
Methods
Nighttime itching interfering with sleep, Rajka-Langeland, and Eczema Area and Severity Index scores were used to assess AD severity. Allergic skin inflammation following epicutaneous sensitization of mice 1 or 2 IL-4Rα R576 alleles (QR and RR) and IL-4Rα Q576 (QQ) controls was assessed by flow cytometric analysis of cells and quantitative RT-PCR …
学术搜索中的文章
B Yang, H Wilkie, M Das, M Timilshina, W Bainter… - Journal of Allergy and Clinical Immunology, 2023