作者
Jérôme Boursier, Maeva Guillaume, Vincent Leroy, Marie Irlès, Marine Roux, Adrien Lannes, Juliette Foucher, Floraine Zuberbuhler, Cyrielle Delabaudière, Justine Barthelon, Sophie Michalak, Jean-Baptiste Hiriart, Jean-Marie Peron, Theophile Gerster, Brigitte Le Bail, Jeremie Riou, Gilles Hunault, Wassil Merrouche, Frederic Oberti, Laurence Pelade, Isabelle Fouchard, Christophe Bureau, Paul Calès, Victor de Ledinghen
发表日期
2019/8/1
期刊
Journal of hepatology
卷号
71
期号
2
页码范围
389-396
出版商
Elsevier
简介
Background & Aims
Advanced liver fibrosis is an important diagnostic target in non-alcoholic fatty liver disease (NAFLD) as it defines the subgroup of patients with impaired prognosis. The non-invasive diagnosis of advanced fibrosis is currently limited by the suboptimal positive predictive value and the grey zone (representing indeterminate diagnosis) of fibrosis tests. Here, we aimed to determine the best combination of non-invasive tests for the diagnosis of advanced fibrosis in NAFLD.
Methods
A total of 938 patients with biopsy-proven NAFLD were randomized 2:1 into derivation and validation sets. All patients underwent liver stiffness measurement with vibration controlled transient elastography (VCTE) and blood fibrosis tests (NAFLD fibrosis score, Fibrosis-4 [FIB4], Fibrotest, Hepascore, FibroMeter). FibroMeterVCTE, which combines VCTE results and FibroMeter markers in a single test, was also calculated in all …
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J Boursier, M Guillaume, V Leroy, M Irlès, M Roux… - Journal of hepatology, 2019