作者
Xiao-Qi Huang, Su Lui, Wei Deng, Raymond CK Chan, Qi-Zhu Wu, Li-Jun Jiang, Jun-Ran Zhang, Zhi-Yun Jia, Xiu-Li Li, Fei Li, Long Chen, Tao Li, Qi-Yong Gong
发表日期
2010/2/15
期刊
Neuroimage
卷号
49
期号
4
页码范围
2901-2906
出版商
Academic Press
简介
BACKGROUND
Spontaneous low-frequency fluctuations (LFF) in the blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal have been shown to reflect cerebral spontaneous neural activity, and the present study attempts to explore the functional changes in the regional brain in patients with schizophrenia using the amplitude of the BOLD signals.
METHODS
A total of 66 treatment-naïve, first-episode schizophrenia (FES) patients and 66 normal age- and sex-matched controls were recruited. Resting-state fMRIs were obtained using a gradient-echo echo-planar imaging sequence. The amplitude of LFF (ALFF) was calculated using REST software. Voxel-based analysis of the ALFF maps between control and patient groups was performed with twos-sample t-tests using SPM2.
RESULTS
Compared to the controls, the FES group showed significantly decreased ALFF in the medial …
学术搜索中的文章
XQ Huang, S Lui, W Deng, RCK Chan, QZ Wu… - Neuroimage, 2010