查看文章

The association of human serum albumin (HSA) and its interaction with drug and other novel compound has garnered keen interest in designing and development for new compounds having profound pharmacokinetic and pharmacodynamic properties. In the present work, binding capacity of N-l-naphthyllaurohydroxamic acid (HAs/Compound 1) with HSA has been evaluated by novel approach involving the fluorescence photo-induced cleavage single molecule observation method. The interaction studies of the synthesized compound and HSA revealed that compound has a strong efficacy to quench the intrinsic fluorescence of HSA and the mechanism of interaction was found to be static type. UV–visible, Fluorescence spectroscopy, Synchronous spectroscopy, Fourier Transform Infrared (FT-IR) and Circular Dichroism (CD) techniques were used to confirm any alteration in the secondary structure of HSA in the …