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The purpose of this study was to assess sleep and breathing in patients with amyotrophic lateral sclerosis (ALS) with bulbar muscle involvement.

Prospective, controlled study of sleep and breathing measured during polysomnography.

University teaching hospital and referral center.

Patients with definite ALS and healthy age-matched control subjects.

Eighteen ALS patients and 10 age-matched control subjects underwent one night of polysomnography. Thirteen patients with ALS were studied for a second night.

The ALS patients had more arousals per hour (p=0.008), more stage 1 sleep (p=0.01), and a shorter total sleep time (TST) (279±69 vs 331.4±55.9 min, mean±SD, p=0.04) than the control subjects. The ALS patients had mild sleep-disordered breathing with a greater apnea/hypopnea index (AHI) than the control subjects (p=0.005). On the second night of …