作者
Aliyah Glover, Lakshmi Pillai, Hafsa Syeda, Aaron Kemp, Mitesh Lotia, Linda Larson-Prior, Tuhin Virmani
发表日期
2020/4/14
来源
Neurology
卷号
94
期号
15 Supplement
出版商
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
简介
Objective
To develop quantitative measures of foot bradykinesia in idiopathic Parkinson’s disease (PD).
Background
Motor blocks occur in Parkinson’s disease (PD) patients during speech, upper limb movements (such as handwriting and repetitive finger tapping) and lower limb movements (gait and repetitive foot tapping). While freezing of gait (FOG) is the most studied of these phenomena, determination of temporal changes in brain connectivity using fMRI or EEG is limited due to motion artifact during active gait. Quantitative measures of lower limb function that correlate with gait would therefore help.
Design/Methods
PD patients with FOG and without (noFOG), and healthy controls (HC) were consented after IRB approval. Subjects walked 8 lengths of a 20′×4′ Zeno pressure sensor impregnated mat (Protokinetics) in their medication ON state at a comfortable pace and fast pace. Subjects wore tri-axial …
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A Glover, L Pillai, H Syeda, A Kemp, M Lotia… - 2020