作者
Giovanni Battista Migliori, Giovanni Sotgiu, Neel R Gandhi, Dennis Falzon, Kathryn DeRiemer, Rosella Centis, Maria-Graciela Hollm-Delgado, Domingo Palmero, Carlos Pérez-Guzmán, Mario H Vargas, Lia D'Ambrosio, Antonio Spanevello, Melissa Bauer, Edward D Chan, H Simon Schaaf, Salmaan Keshavjee, Timothy H Holtz, Dick Menzies, Collaborative Group for Meta-Analysis of Individual Patient Data in MDR-TB
发表日期
2013/7/1
期刊
European Respiratory Journal
卷号
42
期号
1
页码范围
169-179
出版商
European Respiratory Society
简介
The broadest pattern of tuberculosis (TB) drug resistance for which a consensus definition exists is extensively drug-resistant (XDR)-TB. It is not known if additional drug resistance portends worsened patient outcomes. This study compares treatment outcomes of XDR-TB patients with and without additional resistance in order to explore the need for a new definition.
Individual patient data on XDR-TB outcomes were included in a meta-analysis comparing outcomes between XDR alone and three nonmutually exclusive XDR-TB patient groups: XDR plus resistance to all the second-line injectables (sli) and capreomycin and kanamycin/amikacin (XDR+2sli) XDR plus resistance to second-line injectables and to more than one group 4 drug, i.e. ethionamide/protionamide, cycloserine/terizidone or para-aminosalicylic acid (XDR+sliG4) and XDR+sliG4 plus resistance to ethambutol and/or pyrazinamide (XDR+sliG4EZ).
Of …
学术搜索中的文章
GB Migliori, G Sotgiu, NR Gandhi, D Falzon… - European Respiratory Journal, 2013
