作者
Melissa MJ Chua, Matteo Vissani, David D Liu, Frederic LWVJ Schaper, Aaron EL Warren, Rose Caston, Barbara A Dworetzky, Ellen J Bubrick, Rani A Sarkis, G Rees Cosgrove, John D Rolston
发表日期
2023/10
期刊
Epilepsia
卷号
64
期号
10
页码范围
2586-2603
简介
Objective
Here, we report a retrospective, single‐center experience with a novel deep brain stimulation (DBS) device capable of chronic local field potential (LFP) recording in drug‐resistant epilepsy (DRE) and explore potential electrophysiological biomarkers that may aid DBS programming and outcome tracking.
Methods
Five patients with DRE underwent thalamic DBS, targeting either the bilateral anterior (n = 3) or centromedian (n = 2) nuclei. Postoperative electrode lead localizations were visualized in Lead‐DBS software. Local field potentials recorded over 12–18 months were tracked, and changes in power were associated with patient events, medication changes, and stimulation. We utilized a combination of lead localization, in‐clinic broadband LFP recordings, real‐time LFP response to stimulation, and chronic recordings to guide DBS programming.
Results
Four patients (80%) experienced a …
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MMJ Chua, M Vissani, DD Liu, FL Schaper… - Epilepsia, 2023