作者
Matteo Vissani, Chiara Palmisano, Jens Volkmann, Gianni Pezzoli, Silvestro Micera, Ioannis U Isaias, Alberto Mazzoni
发表日期
2021/6/29
期刊
npj Parkinson's Disease
卷号
7
期号
1
页码范围
53
出版商
Nature Publishing Group UK
简介
Excessive beta-band oscillations in the subthalamic nucleus are key neural features of Parkinson’s disease. Yet the distinctive contributions of beta low and high bands, their dependency on striatal dopamine, and their correlates with movement kinematics are unclear. Here, we show that the movement phases of the reach-to-grasp motor task are coded by the subthalamic bursting activity in a maximally-informative beta high range. A strong, three-fold correlation linked beta high range bursts, imbalanced inter-hemispheric striatal dopaminergic tone, and impaired inter-joint movement coordination. These results provide new insight into the neural correlates of motor control in parkinsonian patients, paving the way for more informative use of beta-band features for adaptive deep brain stimulation devices.
引用总数