作者
Alessandro Panarese, Matteo Vissani, Nicolò Meneghetti, Eleonora Vannini, Marina Cracchiolo, Silvestro Micera, Matteo Caleo, Alberto Mazzoni, Laura Restani
发表日期
2023/4/1
期刊
Cerebral Cortex
卷号
33
期号
7
页码范围
4173-4187
出版商
Oxford University Press
简介
The epileptic brain is the result of a sequence of events transforming normal neuronal populations into hyperexcitable networks supporting recurrent seizure generation. These modifications are known to induce fundamental alterations of circuit function and, ultimately, of behavior. However, how hyperexcitability affects information processing in cortical sensory circuits is not yet fully understood. Here, we investigated interlaminar alterations in sensory processing of the visual cortex in a mouse model of focal epilepsy. We found three main circuit dynamics alterations in epileptic mice: (i) a spreading of visual contrast-driven gamma modulation across layers, (ii) an increase in firing rate that is layer-unspecific for excitatory units and localized in infragranular layers for inhibitory neurons, and (iii) a strong and contrast-dependent locking of firing units to network activity. Altogether, our data show that epileptic circuits …
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A Panarese, M Vissani, N Meneghetti, E Vannini… - Cerebral Cortex, 2023