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Recurrent aphthous stomatitis (RAS) is characterized by recurrent episodes of oral ulceration in an otherwise healthy individual. Some reports in the literature indicate that RAS may have immunological, psychological, genetic and microbiological bases.

The purpose of the present study was to investigate, using binary logistic regression analyses, a possible association between the functional IL-1β +3954 (C/T), IL-6 −174 (G/C), IL-10 −1082 (G/A) and TNF-α −308 (G/A) genetic polymorphism and RAS in a sample of Brazilian patients, using a multivariate statistical analysis.

Sixty-four consecutive subjects affected by minor and major forms of RAS and 64 healthy volunteers were genotyped. To investigate the association between the single nucleotide polymorphisms and risk of RAS, binary logistic regression models were fitted. The associations were expressed by odd ratios (ORs) and adjusted …