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Immunostimulants are substances which stimulate the specific and/or non-specific defence systems of fish, enhancing resistance to pathogens during stressful periods. This study evaluated the immune-stimulatory effects of dietary powdered ginger rhizome (Zingiber officinale), in rainbow trout (Oncorhyncus mykiss). The fish were hand-fed with a diet containing 1% powdered ginger rhizome (Z. officinale) once a day at 9: 00 am for 12 weeks. At the end of the experimental period, hematological parameters including hematocrit (Htc), hemoglobin (Hb), red blood cell (RBC), white blood cell (WBC) and immunological parameters including serum lysozyme activity and respiratory burst activity were determined. The results obtained demonstrate that fishes with the supplement of powdered ginger rhizome showed significant immunostimulatory effect, increase in WBC, Hct, RBC values, respiratory burst activity and lysozyme activity when compared with the control group (p< 0.05). These results indicate that dietary powdered ginger rhizome stimulates the immune system in the rainbow trout.© 2013 BluePen Journals Ltd. All rights reserved