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Airborne dusts, noxious gases, endotoxins, and microbial exposures from industrial hog operations (IHOs) have been shown to adversely affect IHO workers’ and neighbors’ health and quality of life. For IHO worker respiratory disease in particular, knowledge gaps remain about the temporal dynamics of exposure-response relations and specific factors that might mitigate exposure and disease burdens. Prior studies to estimate respiratory health effects have focused mainly on comparisons of IHO worker to non-worker populations or pre-vs. post-IHO work shift measurements.