作者
VR Coffman, A Søndergaard Jensen, BB Trabjerg, CB Pedersen, T Sigsgaard, J Olsen, B Hansen, J Schullehner, M Pedersen, L Stayner
发表日期
2020/8/27
期刊
ISEE Conference Abstracts
卷号
2020
期号
1
简介
Background/Aim
Findings from studies examining the effects of prenatal exposure to nitrate from drinking water on fetal growth have been inconsistent, small, and mostly ecologic in nature and none have explicitly examined infant size as measured by body length (BL) or head circumference (HC) at birth. The aim of this study was to assess maternal exposure to nitrate in drinking water and BL and HC at birth in a large population-based cohort.
Methods
Estimates of water contamination by nitrate at each maternal address during pregnancy were linked with individual-level birth registry data to create a cohort of full-term singleton live births in Denmark from Danish parents during 1991-2011, with 848,106 measures of BL and 588,981 of HC. Exposures were modeled both categorically and as log-transformed continuous estimates. Multivariate linear regression with generalized estimating equations was used to assess …