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Igor Kissin, MD, PhD Department of Anesthesiology, University of Alabama School of Medicine, Birmingham, Alabama eneral anesthesia might be viewed as pharmacological intervention used to prevent psychological and somatic adverse effects of surgical trauma and also to create convenient conditions for the surgery. The spectrum of pharmacological actions used in this intervention can include analgesia, anxiolysis, amnesia, unconsciousness, suppression of so-matic motor, cardiovascular and hormonal responses to the surgery, and myorelaxtion. The spectrum of these actions can vary in accordance with the goal of anesthesia. For example, a combination of analgesia, anxiolysis, and amnesia in some situations is prefera-ble to unconsciousness. Some of the actions can be substituted by effects of agents acting peripherally neuromuscular blocking agents for skeletal muscle paralysis or adrenergic …