作者
Clelia Tiziana Storlazzi, Thoas Fioretos, Cecilia Surace, Angelo Lonoce, Angela Mastrorilli, Bodil Strömbeck, Pietro D'Addabbo, Francesco Iacovelli, Crescenzio Minervini, Anna Aventin, Nicole Dastugue, Christa Fonatsch, Anne Hagemeijer, Martine Jotterand, Dominique Mühlematter, Marina Lafage-Pochitaloff, Florence Nguyen-Khac, Claudia Schoch, Marilyn L Slovak, Arabella Smith, Francesc Solè, Nadine Van Roy, Bertil Johansson, Mariano Rocchi
发表日期
2006/3/15
期刊
Human molecular genetics
卷号
15
期号
6
页码范围
933-942
出版商
Oxford University Press
简介
Double minutes (dmin)—circular, extra-chromosomal amplifications of specific acentric DNA fragments—are relatively frequent in malignant disorders, particularly in solid tumors. In acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), dmin are observed in ∼1% of the cases. Most of them consist of an amplified segment from chromosome band 8q24, always including the MYC gene. Besides this information, little is known about their internal structure. We have characterized in detail the genomic organization of 32 AML and two MDS cases with MYC-containing dmin. The minimally amplified region was shown to be 4.26 Mb in size, harboring five known genes, with the proximal and the distal amplicon breakpoints clustering in two regions of ∼500 and 600 kb, respectively. Interestingly, in 23 (68%) of the studied cases, the amplified region was deleted in one of the chromosome 8 homologs …
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CT Storlazzi, T Fioretos, C Surace, A Lonoce… - Human molecular genetics, 2006