作者
Fredrik Mertens, Bertil Johansson, Thoas Fioretos, Felix Mitelman
发表日期
2015/6
来源
Nature Reviews Cancer
卷号
15
期号
6
页码范围
371-381
出版商
Nature Publishing Group UK
简介
Structural chromosome rearrangements may result in the exchange of coding or regulatory DNA sequences between genes. Many such gene fusions are strong driver mutations in neoplasia and have provided fundamental insights into the disease mechanisms that are involved in tumorigenesis. The close association between the type of gene fusion and the tumour phenotype makes gene fusions ideal for diagnostic purposes, enabling the subclassification of otherwise seemingly identical disease entities. In addition, many gene fusions add important information for risk stratification, and increasing numbers of chimeric proteins encoded by the gene fusions serve as specific targets for treatment, resulting in dramatically improved patient outcomes. In this Timeline article, we describe the spectrum of gene fusions in cancer and how the methods to identify them have evolved, and also discuss conceptual implications …
学术搜索中的文章
F Mertens, B Johansson, T Fioretos, F Mitelman - Nature Reviews Cancer, 2015