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Introduction: Obstructive sleep apnea (OSA) is a condition in which there is repetitive and intermittent occlusion of the upper airway (UA) during sleep. OSA can be treated through; continuous positive airway pressure (CPAP), surgery, or oral appliances. Mandibular Advancement Appliance (MAA) is considered a valid alternative, which can be the first choice in simple snorers and mild-moderate OSA. MAA can be either custom-made or non-custom-made, one-piece or two-piece, titratable or non-titratable. While Monoblock designs permit no mouth opening, two-piece appliances vary in permissible lateral jaw movement and in the coupling mechanisms which attach the two plates together. Objectives: measuring the change in UA volume after the use of two different designs of MAA (Monoblock and Biblock) Materials and methods: Twenty patients with diagnosed OSA were divided randomly into two equal groups: Monoblock group ; received Monoblock MAA fabricated using CAD/CAM technique at different advancement levels; 50% then 75% of maximum advancement, Biblock group; received Biblock MAA fabricated using CAD/CAM technique at different advancement levels; 50% then 75% of maximum advancement. UA volume of all patients were evaluated after three months of acclimatization of each stage of advancement through Cone-Beam Computed Tomography (CBCT). Results: Biblock group showed statistically significant increase in UA volume at 75% mandibular advancement level, compared to Monoblock group (p=.001). There was statistically significant increase in UA volume percentage change from baseline to 50 …