作者
Ann H Klopp, Jennifer Moughan, Lorraine Portelance, Brigitte E Miller, Mohammad R Salehpour, Evangeline Hildebrandt, Jenny Nuanjing, David D'Souza, Luis Souhami, William Small Jr, Rakesh Gaur, Anuja Jhingran
发表日期
2013/5/1
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
86
期号
1
页码范围
83-90
出版商
Elsevier
简介
PURPOSE
Intensity modulated radiation therapy (IMRT), compared with conventional 4-field treatment, can reduce the volume of bone marrow irradiated. Pelvic bone marrow sparing has produced a clinically significant reduction in hematologic toxicity (HT). This analysis investigated HT in Radiation Therapy Oncology Group (RTOG) 0418, a prospective study to test the feasibility of delivering postoperative IMRT for cervical and endometrial cancer in a multiinstitutional setting.
METHODS AND MATERIALS
Patients in the RTOG 0418 study were treated with postoperative IMRT to 50.4 Gy to the pelvic lymphatics and vagina. Endometrial cancer patients received IMRT alone, whereas patients with cervical cancer received IMRT and weekly cisplatin (40 mg/m2). Pelvic bone marrow was defined within the treatment field by using a computed tomography density-based autocontouring algorithm. The volume of bone …
学术搜索中的文章
AH Klopp, J Moughan, L Portelance, BE Miller… - International Journal of Radiation Oncology* Biology …, 2013