作者
Raquel Bragante Gritte, Talita Souza-Siqueira, Eliane Borges da Silva, Laiane Cristina dos Santos de Oliveira, Rodrigo Cerqueira Borges, Heloísa H de Oliveira Alves, Laureane Nunes Masi, Gilson Masahiro Murata, Renata Gorjão, Adriana Cristina Levada-Pires, Antônio Carlos Nogueira, Tânia Cristina Pithon-Curi, Ricardo Bentes de Azevedo, Francisco Garcia Soriano, Rui Curi, Marcel Cerqueira Cesar Machado
发表日期
2022/8/1
期刊
Critical Care Explorations
卷号
4
期号
8
页码范围
e0734
出版商
LWW
简介
OBJECTIVES:
This study sought to identify monocyte alterations from septic patients after hospital discharge by evaluating gene expression of inflammatory mediators and monocyte polarization markers. It was hypothesized that sepsis reprograms the inflammatory state of monocytes, causing effects that persist after hospital discharge and influencing patient outcomes.
DESIGN:
The gene expression patterns of inflammatory receptors, M1 and M2 macrophage polarization markers, NLRP3 inflammasome components, and pro-and anti-inflammatory cytokines in monocytes were assessed.
PATIENTS:
Thirty-four patients from the University of São Paulo Hospital, during the acute sepsis phase (phase A), immediately after ICU discharge (phase B), and 3 months (phase C), 6 months (phase D), 1 year (phase E), and 3 years (phase F) after discharge, were included. Patients that died during phases A and B were grouped …
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RB Gritte, T Souza-Siqueira, EB da Silva… - Critical Care Explorations, 2022