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Objective: In the last 3 decades the nanotechnology has impacted researchers with promising results and newer hope in the treatment of complex diseases. Apart from other nanocarriers dendrimers have shown to be one of the most successful nanocarrier as per as the drug delivery is concerned. The present review article is an attempt to comprehensively compile the work in the dual or cocktail delivery using different dendrimers and specially PAMAM. Methods: Bibliographic information were collected and analysed from text books and peer reviewed journals, consulting worldwide accepted scienti c databases from the libraries and internet sources. Dendrimers are highly branched macromolecular carriers with the size below 100 nm. The nanometric size and tailor made functionality provides another opportunity for the drug delivery. In the recent past, the dual or cocktail delivery of drugs and genes has opened a new avenue in the treatment of diseases with multiple drug therapy. This is a step ahead possibility shown by the dendrimers which is purely due to its unique features and properties. The applications of Conclusion: dendrimers extends even beyond drug delivery ie in diagnostics, non pharmaceutical applications etc. The combined delivery of siRNA and drugs has better potential in overcoming the drug resistance in the diseases such as breast cancer others.