作者
Patrice Forget, Jean-Pascal Machiels, Pierre G Coulie, Martine Berliere, Alain J Poncelet, Bertrand Tombal, Annabelle Stainier, Catherine Legrand, Jean-Luc Canon, Yann Kremer, Marc De Kock
发表日期
2013/12
期刊
Annals of surgical oncology
卷号
20
页码范围
650-660
出版商
Springer US
简介
Background
Inflammation is associated with a worse outcome in cancer and neutrophil:lymphocyte ratio (NLR) is a strong prognostic value. In cancer, nonsteroidal anti-inflammatory drugs (NSAIDs) could be of interest. We investigated the prognostic significance of NLR and the impact of intraoperative NSAIDs in cancer surgeries.
Methods
We performed an observational study in early breast, kidney, and lung cancers (357, 227, and 255 patients) with uni- and multivariate analyses (Cox model).
Results
In breast cancer (Centre 1), NLR ≥ 4 is associated with a higher risk of relapse (hazards ratio (HR) = 2.41; 95 % confidence interval (CI) 1.01–5.76; P = 0.048). In breast cancer (Centre 2), NLR ≥ 3 is associated with a higher risk of relapse (HR = 4.6; 95 % CI 1.09–19.1; P = 0.04) and higher mortality (HR = 4.0; 95 % CI 1 …
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P Forget, JP Machiels, PG Coulie, M Berliere… - Annals of surgical oncology, 2013