作者
Jan P Van Meerbeeck, Gijs WPM Kramer, Paul EY Van Schil, Catherine Legrand, Egbert F Smit, Franz Schramel, Vivianne C Tjan-Heijnen, Bonne Biesma, Channa Debruyne, Nico Van Zandwijk, Ted AW Splinter, Giuseppe Giaccone
发表日期
2007/3/21
期刊
Journal of the National Cancer Institute
卷号
99
期号
6
页码范围
442-450
出版商
Oxford University Press
简介
Background
Induction chemotherapy before surgical resection increases survival compared with surgical resection alone in patients with stage IIIA-N2 non–small-cell lung cancer (NSCLC). We hypothesized that, following a response to induction chemotherapy, surgical resection would be superior to thoracic radiotherapy as locoregional therapy.
Methods
Selected patients with histologic or cytologic proven stage IIIA-N2 NSCLC were given three cycles of platinum-based induction chemotherapy. Responding patients were subsequently randomly assigned to surgical resection or radiotherapy. Survival curves were estimated using Kaplan–Meier analyses from time of randomization.
Results
Induction chemotherapy resulted in a response rate of 61% (95% confidence interval [CI] = 57% to 65%) among the 579 eligible patients. A total of 167 patients were …
引用总数
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