作者
Zhiyuan Wu, Huiying Pan, Di Liu, Di Zhou, Lixin Tao, Jie Zhang, Xiaonan Wang, Xia Li, Youxin Wang, Wei Wang, Xiuhua Guo
发表日期
2021/8
期刊
Journal of Diabetes
卷号
13
期号
8
页码范围
672-680
出版商
Wiley Publishing Asia Pty Ltd
简介
Background
The relationship of immunoglobulin G (IgG) glycosylation with diabetes and diabetic nephropathy has been reported, but its role in diabetic retinopathy (DR) remains unclear. We aimed to investigate and validate the association of IgG glycosylation with DR.
Methods
We analyzed the IgG N‐linked glycosylation profile and primarily selected candidate glycans by lasso (least absolute shrinkage and selection operator) regression analysis in the discovery population. The findings were validated in the replication population using a binary logistics model. The association between the significant glycosylation panel and clinical features was illustrated with Spearman's coefficient. The results were confirmed by sensitivity analyses.
Results
Among 16 selected glycan candidates using lasso, two IgG glycans (GP15, GP20) and two derived traits (IGP32, IGP54) were identified and validated to be significantly …
学术搜索中的文章
Z Wu, H Pan, D Liu, D Zhou, L Tao, J Zhang, X Wang… - Journal of Diabetes, 2021
