作者
Cheng-Chia Lee, Mary Lee Vance, Zhiyuan Xu, Chun-Po Yen, David Schlesinger, Blair Dodson, Jason Sheehan
发表日期
2014/4/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
99
期号
4
页码范围
1273-1281
出版商
Oxford University Press
简介
Context
The role of stereotactic radiosurgery (SRS) in acromegaly is being assessed.
Objective
We evaluated the efficacy and safety of SRS for patients with acromegaly. Prognostic factors related to outcomes were also analyzed.
Design
This was a retrospective study of patients treated with SRS at the University of Virginia; the data were collected from 1989 to 2012, with a median follow-up of 61.5 months.
Patients
A total of 136 patients underwent SRS for acromegaly. Diagnosis of acromegaly was based on the combination of clinical features and biochemical assessment, including the serum GH level and age- and gender-matched serum IGF-1 level. All patients underwent a complete endocrine evaluation, neuroimaging study, and ophthalmic examinations before SRS.
Main Outcome Measures
After withdrawal of GH …
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CC Lee, ML Vance, Z Xu, CP Yen, D Schlesinger… - The Journal of Clinical Endocrinology & Metabolism, 2014