作者
Andre C Kalil, Aneesh K Mehta, Thomas F Patterson, Nathaniel Erdmann, Carlos A Gomez, Mamta K Jain, Cameron R Wolfe, Guillermo M Ruiz-Palacios, Susan Kline, Justino Regalado Pineda, Anne F Luetkemeyer, Michelle S Harkins, Patrick EH Jackson, Nicole M Iovine, Victor F Tapson, Myoung-don Oh, Jennifer A Whitaker, Richard A Mularski, Catharine I Paules, Dilek Ince, Jin Takasaki, Daniel A Sweeney, Uriel Sandkovsky, David L Wyles, Elizabeth Hohmann, Kevin A Grimes, Robert Grossberg, Maryrose Laguio-Vila, Allison A Lambert, Diego Lopez de Castilla, EuSuk Kim, LuAnn Larson, Claire R Wan, Jessica J Traenkner, Philip O Ponce, Jan E Patterson, Paul A Goepfert, Theresa A Sofarelli, Satish Mocherla, Emily R Ko, Alfredo Ponce de Leon, Sarah B Doernberg, Robert L Atmar, Ryan C Maves, Fernando Dangond, Jennifer Ferreira, Michelle Green, Mat Makowski, Tyler Bonnett, Tatiana Beresnev, Varduhi Ghazaryan, Walla Dempsey, Seema U Nayak, Lori Dodd, Kay M Tomashek, John H Beigel, Angela Hewlett, Barbara S Taylor, Jason E Bowling, Ruth C Serrano, Nadine G Rouphael, Zanthia Wiley, Varun K Phadke, Laura Certain, Hannah N Imlay, John J Engemann, Emmanuel B Walter, Jessica Meisner, Sandra Rajme, Joanne Billings, Hyun Kim, Jose A Martinez-Orozco, Nora Bautista Felix, Sammy T Elmor, Laurel R Bristow, Gregory Mertz, Nestor Sosa, Taison D Bell, Miranda J West, Marie-Carmelle Elie-Turenne, Jonathan Grein, Fayyaz Sutterwala, Pyoeng Gyun Choe, Chang Kyung Kang, Hana M El Sahly, Kevin S Rhie, Rezhan H Hussein, Patricia L Winokur, Ayako Mikami, Sho Saito, Constance A Benson, Kimberly McConnell, Mezgebe Berhe, Emma Dishner, Maria G Frank, Ellen Sarcone, Pierre-Cedric B Crouch, Hannah Jang, Nikolaus Jilg, Katherine Perez, Charles Janak, Valeria D Cantos, Paulina A Rebolledo, John Gharbin, Barry S Zingman, Paul F Riska, Ann R Falsey, Edward E Walsh, Angela R Branche, Henry Arguinchona, Christa Arguinchona, Jason W Van Winkle, Diego F Zea, Jongtak Jung, Kyoung-Ho Song, Hong Bin Kim, Jay Dwyer, Emma Bainbridge, David C Hostler, Jordanna M Hostler, Brian T Shahan, Lanny Hsieh, Alpesh N Amin, Miki Watanabe, William R Short, Pablo Tebas, Jillian T Baron, Neera Ahuja, Evelyn Ling, Minjoung Go, Otto O Yang, Jenny Ahn, Rubi Arias, Rekha R Rapaka, Fleesie A Hubbard, James D Campbell, Stuart H Cohen, George R Thompson, Melony Chakrabarty, Stephanie N Taylor, Najy Masri, Alisha Lacour, Tida Lee, Tahaniyat Lalani, David A Lindholm, Ana Elizabeth Markelz, Katrin Mende, Christopher J Colombo, Christina Schofield, Rhonda E Colombo
发表日期
2021/12/1
期刊
The lancet respiratory medicine
卷号
9
期号
12
页码范围
1365-1376
出版商
Elsevier
简介
Background
Functional impairment of interferon, a natural antiviral component of the immune system, is associated with the pathogenesis and severity of COVID-19. We aimed to compare the efficacy of interferon beta-1a in combination with remdesivir compared with remdesivir alone in hospitalised patients with COVID-19.
Methods
We did a double-blind, randomised, placebo-controlled trial at 63 hospitals across five countries (Japan, Mexico, Singapore, South Korea, and the USA). Eligible patients were hospitalised adults (aged ≥18 years) with SARS-CoV-2 infection, as confirmed by a positive RT-PCR test, and who met one of the following criteria suggestive of lower respiratory tract infection: the presence of radiographic infiltrates on imaging, a peripheral oxygen saturation on room air of 94% or less, or requiring supplemental oxygen. Patients were excluded if they had either an alanine aminotransferase or an …
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AC Kalil, AK Mehta, TF Patterson, N Erdmann… - The lancet respiratory medicine, 2021