作者
Serena Gumusoglu, Casee R Meincke, Michaela Kiel, Alexandria Betz, Virginia Nuckols, Lyndsey DuBose, Jessica Steidele, Eileen Sweezer, Donna Santillan, Amy K Stroud, Gary L Pierce, Mark K Santillan
发表日期
2024/3/1
期刊
Pregnancy hypertension
卷号
35
页码范围
12-18
出版商
Elsevier
简介
Objectives
Preeclampsia and depression in pregnancy are among the most prevalent obstetric disorders with no known cures. While depression and preeclampsia each increase risk for the other, shared mechansisms are unclear. One possibility is low levels of Indoleamine 2,3 dioxygenase (IDO), which links immune dysregulation and oxidative arterial damage resulting in poor vascular function in both preeclampsia and depression. We hypothesized low circulating IDO activity levels in pregnancy would correspond to poor vascular function and depression symptoms.
Study design
In this nested case-control study, clinical, demographic, and biologic data from a cohort of pregnant women recruited to longitudinal studies measuring noninvasive vascular function and circulating factors were analyzed.
Main outcome measure
IDO activity across all three trimesters of pregnancy was measured using a colorimetric assay …
学术搜索中的文章
S Gumusoglu, CR Meincke, M Kiel, A Betz, V Nuckols… - Pregnancy hypertension, 2024