作者
Iheanyi Okpala, Obike Ibegbulam, Augustine Duru, Sunday Ocheni, Ifeoma Emodi, Anthony Ikefuna, Garba Umar, Isaac Asinobi, Anazoeze Madu, Augustine Okoye, Tessy Nwagha, Uche Oguonu, Ify Uamai, Obineche Agwu, Charles Nonyelu, Uche Anike, Kingsley Agu, Chukwudi Anigbo, Awele Chukwura, Ogechukwu Ugwu, Sagrario Herrada
发表日期
2011/7
期刊
Apmis
卷号
119
期号
7
页码范围
442-448
出版商
Blackwell Publishing Ltd
简介
Okpala I, Ibegbulam O, Duru A, Ocheni S, Emodi I, Ikefuna A, Umar G, Asinobi I, Madu A, Okoye A, Nwagha T, Oguonu U, Uamai I, Agwu O, Nonyelu C, Anike U, Agu K, Anigbo C, Chukwura A, Ugwu O, Herrada S. Pilot study of omega‐3 fatty acid supplements in sickle cell disease. APMIS 2011; 119: 442–8.
In a previous retrospective study, it was observed that the greater the amounts of the omega‐3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in the blood, the lesser the number of complications of sickle cell disease (SCD) and the higher the steady state haemoglobin level. SCD causes ischaemia‐reperfusion injury and inflammation; which can be ameliorated by a metabolite of DHA that down‐regulates expression of pro‐inflammatory genes. The objectives of this prospective pilot study were to evaluate the effects of DHA and EPA supplements in SCD, and test the hypothesis that …
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I Okpala, O Ibegbulam, A Duru, S Ocheni, I Emodi… - Apmis, 2011