作者
Xuan Zhou, Margaret Nowicki, Haitao Cui, Wei Zhu, Xiuqi Fang, Shida Miao, Se-Jun Lee, Michael Keidar, Lijie Grace Zhang
发表日期
2017/5/1
期刊
Carbon
卷号
116
页码范围
615-624
出版商
Pergamon
简介
Articular cartilage repair and regeneration are a challenging problem worldwide due to the extremely weak inherent regenerative capacity of cartilaginous tissue. As an emerging tissue engineering scaffold fabrication technology, 3D bioprinting has shown great promise in fabricating customizable artificial tissue matrices with hierarchical structures. The goal of the present study is to investigate 3D bioprinted graphene oxide (GO)-doped gelatin–based scaffolds for promoting chondrogenic differentiation of human bone marrow mesenchymal stem cells (MSCs). In the current study, GO-gelatin methacrylate (GelMA)–poly (ethylene glycol) diacrylate (PEGDA) was prepared as a biocompatible photopolymerizable bioink. GO, a multifunctional carbon based nanomaterial, was incorporated into the bioink for promoting chondrogenic differentiation. Finally, the 3D printed GelMA-PEGDA-GO scaffold with hierarchical …
引用总数
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