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Datura, a wild plant from solanaceae family is very well known for its poisonous and medicinal properties. It contains a wide variety of phytoconstituents such as alkaloids, essential oils, flavonoids, tannins, steroids, glycosides etc. They are responsible for various medicinal properties. Wide variety of pharmacological activities of different species of datura have been reported so far such as anti-inflammatory, anti-diarrhoeal, hypoglycemic activity, anti-viral activity etc. Daturastramonium has been used for curing various ailments including ulcer, wounds, gout, fever, asthma, toothache etc. The aim of present study is to investigate the anti-inflammatory activity of seed extract of Daturastramonium against carrageenan induced paw edema model in albino wistar rats.