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The purpose of writing this review to compile the current technological development of floating drug delivery system (FDDS), advantages and future potential for oral controlled drug delivery. The review includes various approaches which are currently utilized in the prolongation of the gastric residence time (GRT) and their classification. This review also summarizes various in vitro and in vivo techniques to evaluate the performance and application of these systems. in incomplete drug release from the DDS, leading to diminished efficacy of the administered dose. Thus, control of placement of a DDS in a specific region of the GI tract offers numerous advantages, especially for drugs exhibiting an absorption window in the GI tract or drugs with a stability problem. Overall, the intimate contact of the DDS with the absorbing membrane has the potential to maximize drug absorption and may also influence the rate of drug absorption. These considerations have led to the development of oral controlled release (CR) dosage forms possessing gastric retention capabilities.[1] One of the most feasible approaches for achieving a prolonged and predictable drug delivery profile in the GI tract is to control the gastric residence time (GRT) using gastroretentive dosage forms (GRDFs). GRDF can remain in the gastric region for several hours and hence significantly prolong the GRT of the drugs. Prolonged gastric retention improves the bioavailability, reduces drug waste, and improves solubility of drugs that are less soluble in a high pH environment. It has applications also for local drug delivery to the stomach and proximal small intestines. Gastroretention helps to …