作者
Pedro Eduardo Ferreira, Maria Isabel Veiga, Isa Cavaco, J Paulo Martins, Björn Andersson, Shaliya Mushin, Abullah S Ali, Achuyt Bhattarai, Vera Ribeiro, Anders Björkman, José Pedro Gil
发表日期
2008/2/1
期刊
Therapeutic drug monitoring
卷号
30
期号
1
页码范围
10-15
出版商
LWW
简介
Artemisinin-based combination therapy is a main strategy for malaria control in Africa. Zanzibar introduced this new treatment policy in 2003. The authors have studied the prevalence of a number of functional single nucleotide polymorphisms (SNPs) in genes associated with the elimination of the artemisinin-based combination therapy compounds in use in Zanzibar to investigate the frequencies of subgroups potentially at higher drug exposure and therefore possible higher risk of toxicity.
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PE Ferreira, MI Veiga, I Cavaco, JP Martins… - Therapeutic drug monitoring, 2008