作者
Adriaan J Van Der Meer, Bart J Veldt, Jordan J Feld, Heiner Wedemeyer, Jean-François Dufour, Frank Lammert, Andres Duarte-Rojo, E Jenny Heathcote, Michael P Manns, Lorenz Kuske, Stefan Zeuzem, W Peter Hofmann, Robert J De Knegt, Bettina E Hansen, Harry LA Janssen
发表日期
2012/12/26
期刊
Jama
卷号
308
期号
24
页码范围
2584-2593
出版商
American Medical Association
简介
Context
Chronic hepatitis C virus (HCV) infection outcomes include liver failure, hepatocellular carcinoma (HCC), and liver-related death.
Objective
To assess the association between sustained virological response (SVR) and all-cause mortality in patients with chronic HCV infection and advanced hepatic fibrosis.
Design, Setting, and Patients
An international, multicenter, long-term follow-up study from 5 large tertiary care hospitals in Europe and Canada of 530 patients with chronic HCV infection who started an interferon-based treatment regimen between 1990 and 2003, following histological proof of advanced hepatic fibrosis or cirrhosis (Ishak score 4-6). Complete follow-up ranged between January 2010 and October 2011.
Main Outcome Measures
All-cause mortality. Secondary outcomes were liver failure, HCC, and liver-related mortality or liver transplantation.
Results
The 530 study patients were followed up for a …
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