作者
A Notarnicola, C Hellstrom, B Horuluoglu, C Preger, F Bonomi, B De Paepe, J De Bleecker, AJ Van der Kooi, M De Visser, S Sacconi, P Machado, UA Badrising, A Rietveld, G Pruijn, S Rothwell, JB Lilleker, H Chinoy, O Benveniste, E Svenungsson, H Idborg, PJ Jakobsson, Peter Nilsson, IE Lundberg
发表日期
2023/6/1
来源
Annals of the Rheumatic Diseases
卷号
82
期号
Suppl 1
页码范围
574-574
出版商
BMJ Publishing Group Ltd
简介
Background
Autoantibodies are found in up to 80% of patients with idiopathic inflammatory myopathies (IIM) and are associated with distinct clinical phenotypes [1]. Autoantibodies targeting cytosolic 5´-nucleotidase 1A (anti-cN1A) are currently the only known serum biomarker for the subgroup inclusion body myositis (IBM) (2), although detected even in other autoimmune diseases.
Objectives
To identify new autoimmune targets in IIM by antigen bead array assay.
Methods
In a first cross-sectional exploratory study, 357 antigens representing 268 proteins were incubated with plasma samples from 219 IIM (108 Polymyositis (PM), 80 Dermatomyositis (DM) and 31 IBM) patients, 349 Systemic Lupus Erythematosus (SLE) patients and 306 population controls for screening of IgG reactivity by antigen bead array. All samples were identified in the local biobank of the Rheumatology clinic, Karolinska University Hospital …
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