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Objective:

To explore the association between multiple umbilical cord blood proteins and severity of hypoxic-ischemic encephalopathy as defined by continuous multichannel electroencephalography.

Design:

A prospective case-control cohort study, which was divided into separate exploratory and validation cohorts.

Setting:

A single tertiary neonatal intensive care facility.

Patients:

The study recruited full-term infants with perinatal asphyxia and controls. Identical procedures were used to recruit a representative exploratory sample (n= 30) and a subsequent validation cohort (n= 100).

Intervention:

All had umbilical cord blood drawn and biobanked at delivery, continuous multichannel electroencephalography commenced in the first 24 hours, and a modified Sarnat score assigned. Analysis of 37 potential cord blood protein markers of hypoxic-ischemic encephalopathy was performed using Luminex multiplex assays …