作者
Alessandro Antonelli, Andrea Minervini, Marco Sandri, Roberto Bertini, Riccardo Bertolo, Marco Carini, Maria Furlan, Alessandro Larcher, Guglielmo Mantica, Andrea Mari, Francesco Montorsi, Carlotta Palumbo, Francesco Porpiglia, Paola Romagnani, Claudio Simeone, Carlo Terrone, Umberto Capitanio
发表日期
2018/11/1
期刊
European urology
卷号
74
期号
5
页码范围
661-667
出版商
Elsevier
简介
Background
The hypothesis that renal function could influence oncological outcomes is supported by anecdotal literature.
Objective
To determine whether estimated glomerular filtration rate (eGFR) is related to cancer-specific mortality (CSM) in patients who had undergone surgery for renal cell carcinoma (RCC).
Design, setting, and participants
A retrospective analysis of 3457 patients who underwent radical (39%) or partial nephrectomy (61%) for cT1–2 RCC between 1990 and 2015.
Outcome measurements and statistical analysis
The eGFR was calculated by the Chronic Kidney Disease Epidemiology Collaboration equation. CSM was analyzed in a multivariable competing-risk framework, estimating the subdistribution hazard ratio (SHR) accounting for deaths from other causes. The relationship between eGFR and CSM was investigated from multiple statistical approaches—extended Cox regression with eGFR …
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A Antonelli, A Minervini, M Sandri, R Bertini, R Bertolo… - European urology, 2018