作者
Andrea Mari, Shoji Kimura, Beat Foerster, Mohammad Abufaraj, David D'Andrea, Kilian M Gust, Shahrokh F Shariat
发表日期
2018/6/1
来源
Urologic oncology: seminars and original investigations
卷号
36
期号
6
页码范围
293-305
出版商
Elsevier
简介
Purpose
Lymphovascular invasion (LVI) is an important step in bladder cancer cell dissemination. We aimed to perform a systematic review and meta-analysis of the literature to assess the prognostic value of LVI in radical cystectomy (RC) specimens.
Patients and methods
A systematic review and meta-analysis of the last 10 years was performed using the MEDLINE, EMBASE, and the Cochrane libraries in July 2017. The analyses were performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement.
Results
We retrieved 65 studies (including 78,107 patients) evaluating the effect of LVI on oncologic outcomes in patients treated with RC. LVI was reported in 35.4% of patients. LVI was associated with disease recurrence (pooled hazard ratio [HR] = 1.57; 95% CI: 1.45–1.70) and cancer-specific mortality (CSM) (pooled HR = 1.59; 95% CI: 1.48–1.73) in all …
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A Mari, S Kimura, B Foerster, M Abufaraj, D D'Andrea… - Urologic oncology: seminars and original …, 2018